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csf1r inhibitor plx5622  (MedChemExpress)


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    MedChemExpress csf1r inhibitor plx5622
    Csf1r Inhibitor Plx5622, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 86 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/csf1r inhibitor plx5622/product/MedChemExpress
    Average 96 stars, based on 86 article reviews
    csf1r inhibitor plx5622 - by Bioz Stars, 2026-02
    96/100 stars

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    csf1r inhibitor plx3397  (MedChemExpress)
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    a The levels of 31 cytokines and chemokines in the plasma of the two groups with a Luminex liquid chip (red, upregulated; blue, downregulated; n = 5, each group). b, c The expression of CD11b (microglial marker), <t>CSF1R</t> (microglial marker), and Ki67 in the PFC and hippocampus (HIP). d Representative high-magnification photomicrographs showing Iba1 immunoreactivity in the PFC of control and SD-treated mice. e – k Changes in microglial density and morphology in the PFC and HIP of the two groups. * P < 0.05, ** P < 0.01, *** P < 0.001. Scale bars = 50 μm in d. Statistical analysis was performed using unpaired t test or Mann-Whitney test.
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    a The levels of 31 cytokines and chemokines in the plasma of the two groups with a Luminex liquid chip (red, upregulated; blue, downregulated; n = 5, each group). b, c The expression of CD11b (microglial marker), CSF1R (microglial marker), and Ki67 in the PFC and hippocampus (HIP). d Representative high-magnification photomicrographs showing Iba1 immunoreactivity in the PFC of control and SD-treated mice. e – k Changes in microglial density and morphology in the PFC and HIP of the two groups. * P < 0.05, ** P < 0.01, *** P < 0.001. Scale bars = 50 μm in d. Statistical analysis was performed using unpaired t test or Mann-Whitney test.

    Journal: Translational Psychiatry

    Article Title: Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner

    doi: 10.1038/s41398-025-03525-x

    Figure Lengend Snippet: a The levels of 31 cytokines and chemokines in the plasma of the two groups with a Luminex liquid chip (red, upregulated; blue, downregulated; n = 5, each group). b, c The expression of CD11b (microglial marker), CSF1R (microglial marker), and Ki67 in the PFC and hippocampus (HIP). d Representative high-magnification photomicrographs showing Iba1 immunoreactivity in the PFC of control and SD-treated mice. e – k Changes in microglial density and morphology in the PFC and HIP of the two groups. * P < 0.05, ** P < 0.01, *** P < 0.001. Scale bars = 50 μm in d. Statistical analysis was performed using unpaired t test or Mann-Whitney test.

    Article Snippet: To deplete microglia in the brain, mice were injected with the CSF1R inhibitor PLX3397 (pexidartinib, PLX, MedChemExpress, Cat# HY-16749, USA) dissolved in 5% dimethyl sulfoxide (DMSO), 10% sulfobutylether-β-cyclodextrin (SBE-β-CD) based on previous studies [ ].

    Techniques: Clinical Proteomics, Luminex, Expressing, Marker, Control, MANN-WHITNEY